Formulation and Characterization of Zingiberol Loaded Microsphere for Motion Sickness
DOI:
https://doi.org/10.7439/ijap.v8i1.5258Keywords:
Zingiberol, Microspheres, Ionotropic gelation method, Evaluation parametersAbstract
The present research work involve the development of Zingiberol as the treatment of motion sickness. The Zingiberol microsphere was formulated by Ionotropic gelation method using different polymers in different ratio depending on RSM method. The prepared formulations were optimized on the basis of dependent variables like particle size (mg), entrapment efficiency etc. The SEM photographs of Zingiberol microsphere before dissolution shows the spherical and smooth surface whereas after dissolution the pores and crevices were shown which is indicating that the microsphere are showing drug release by diffusion mechanism. The microsphere formulations were able to sustain the release of drug both in vitro and in vivo. In the stability studies no significant change in drug entrapment release characteristics of the microspheres.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).