Formulation and evaluation of raloxifene hydrochloride tabletswith improved dissolution profile

Authors

  • Smita Nayak Department of Quality Assurance, Gahlot Institute of Pharmacy, Koparkhairane, Navi Mumbai-400709, Maharashtra
  • Sanidhya Suryawanshi Department of Quality Assurance, Gahlot Institute of Pharmacy, Koparkhairane, Navi Mumbai-400709, Maharashtra
  • Bhaskar Vaidhun Department of Quality Assurance, Gahlot Institute of Pharmacy, Koparkhairane, Navi Mumbai-400709, Maharashtra

DOI:

https://doi.org/10.7439/ijap.v5i6.3761

Abstract

The objective of this research activity was to formulate and evaluate Raloxifene Hydrochloride (RLX HCl) tablets (BCS class II drug) with enhanced aqueous solubility thereby achieving a formulation with improved dissolution characteristics. Tablets were prepared by incorporating excipients such as disintegrant, solubilizer, wetting agent and evaluated for various pre compression and post compression parameters. Also assay and in-vitro dissolution studies were performed. Formula RLX HCl 27 containing disintegrant Ac-di-sol (15 mg-intragranular and 5 mg- extragranular) and solubilizerDimethyl Sulfoxide (DMSO- 10 mg) was selected as the best optimised formula.Optimised formula was scaled up and stability studies were carried out according to the stability protocol. The results indicated that the formulation was stable and had improved dissolution profile as compared to marketed tablet.

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Published

2016-12-30

Issue

Vol. 5 No. 6 (2016): Nov-Dec

Section

Research Articles

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How to Cite

1.
Formulation and evaluation of raloxifene hydrochloride tabletswith improved dissolution profile. Int J Adv Pharm [Internet]. 2016 Dec. 30 [cited 2026 Jan. 3];5(6):127-39. Available from: https://ssjournals.co.in/index.php/ijap/article/view/3761
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