Development and validation of UV spectrophotometric method for simultaneous estimation of propranolol hydrochloride and rosuvastatin calcium in bulk drug and pharmaceutical dosage form

Authors

  • Namdeo G Shinde Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara, Shivaji University (MH) 415 004.
  • Nagesh H. Aloorkar Department of Pharmaceutics, Satara College of Pharmacy, Degaon, Satara, Shivaji University (MH) 415 004.

DOI:

https://doi.org/10.7439/ijap.v4i5.2507

Keywords:

prescription pattern, hypertension, antihypertensive drugs, geriatric population.

Abstract

A new, simple and sensitive UV spectrophotometric method has been developed for simultaneous quantitative determination of propranolol hydrochloride and rosuvastatin calcium in bulk and pharmaceutical dosage form. This is achieved by simultaneous equation (Vierodts method) and absorbance ratio (Q- point) method. Propranolol hydrochloride and rosuvastatin calcium exhibits maximum absorbance at 289 nm and 243 nm respectively in methanol as solvent. Beers law was found to be obeyed in the concentration range 2-40 g/ml for propranolol hydrochloride and 2-42 g/ml or rosuvastatin calcium. Method were validated for linearity, accuracy, precision, LOD, LOQ as per ICH guidelines.

Downloads

Download data is not yet available.

Downloads

Published

2015-10-21

Issue

Vol. 4 No. 5 (2015): Sep-Oct

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

1.
Development and validation of UV spectrophotometric method for simultaneous estimation of propranolol hydrochloride and rosuvastatin calcium in bulk drug and pharmaceutical dosage form. Int J Adv Pharm [Internet]. 2015 Oct. 21 [cited 2024 Oct. 18];4(5):55-9. Available from: https://ssjournals.co.in/index.php/ijap/article/view/2507

Most read articles by the same author(s)

<< < 2 3 4 5 6 7 8 9 > >>