Chromatographic Development of validated analytical method for the estimation of tapentadol and paracetamol in combined dosage form

Authors

  • Manoj Charde Government College of Pharmacy, Kathora Naka, Amravati-444604, Maharashtra
  • Ashwini A. Patil Government College of Pharmacy, Kathora Naka, Amravati-444604, Maharashtra
  • Jitendra Kumar Government College of Pharmacy, Kathora Naka, Amravati-444604, Maharashtra
  • A. S. Welankiwar Government College of Pharmacy, Kathora Naka, Amravati-444604, Maharashtra

DOI:

https://doi.org/10.7439/ijap.v2i4.1409

Abstract

A simple, sensitive an isocratic RP-HPLC method for the estimation of TAP (Tapentadol) and PARA (Paracetamol) in combined dosage form using Inertsil ODS C-18 column (250.6 mm, 5 ) in an isocratic mode with mobile phase comprising Buffer (1mL TEA) : ACN : MeOH in the ratio of (75:20:5 v/v/v). The flow rate was 1.2 mL/ min and effluent was monitored at 220 nm. The retention times were found to be 6.88 min for TAP and 3.78 min for PARA. The assay exhibited a linear dynamic range of 11.89- 28.55 g/mL for TAP and 64.95- 155.90 g/mL for PARA .The calibration curves were linear (r = 0.999 for TAP and r = 0.9996 for PARA) over the entire linear range.

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Published

2013-08-30

Issue

Vol. 2 No. 4 (2013): Jul-Aug

Section

Research Articles

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How to Cite

1.
Chromatographic Development of validated analytical method for the estimation of tapentadol and paracetamol in combined dosage form. Int J Adv Pharm [Internet]. 2013 Aug. 30 [cited 2024 Sep. 8];2(4):45-54. Available from: https://ssjournals.co.in/index.php/ijap/article/view/1409

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