The Study of Hypoglycemic effect of microencapsulated Glimepiride In Long Evans Rats

Authors

  • Md. Shamsuddin Sultan Khan The University of Asia Pacific, Department of Pharmacy.
  • A.S.M. Ismaiel Hussain The University of Asia Pacific, Department of Pharmacy
  • Md. Atiqur Rahim The University of Asia Pacific, Department of Pharmacy
  • Sharmina Islam The University of Asia Pacific, Department of Pharmacy
  • Md. Mesbah Uddin Talukder The University of Asia Pacific, Department of Pharmacy

DOI:

https://doi.org/10.7439/ijap.v1i1.1400

Abstract

In this study glimepiride was used as a model drug to evaluate the hypoglycemic effect of microencapsulated or mucoadhesive drug delivery system. Sodium alginate based Microbeads of Glimepiride was prepared using Glycerine monostearate (GMS) for oral sustained release by Orifice-ionic gelation method. The microbeads were evaluated for physical appearance, floating properties, In-Vitro release study and In-Vivo evaluation. The microbeads were free flowing, spherical in shape and have the good content of uniformity of drugs. The spherical microbeads of 2 mm diameter were prepared by dropping sodium alginate incorporated with Glimepiride solution into aqueous solution of calcium chloride, causing the precipitation of calcium alginate. These Microbeads released the drug for a prolonged residence time of more than 2 hours. The hypoglycemic effect of the mucoadhesive floating drug delivery system is a valuable method for the long term delivery of Glimepiride on Long Evans Rats.

Downloads

Author Biography

  • Md. Shamsuddin Sultan Khan, The University of Asia Pacific, Department of Pharmacy.
    Research Associate

Downloads

Published

2013-01-01

Issue

Section

Research Articles

How to Cite

1.
The Study of Hypoglycemic effect of microencapsulated Glimepiride In Long Evans Rats. Int J Adv Pharm [Internet]. 2013 Jan. 1 [cited 2025 Jul. 26];1(1):16-21. Available from: https://ssjournals.co.in/index.php/ijap/article/view/1400