Estimation of Valsartan in Pharmaceutical Formulation by Area under Curve Spectrophotometric Method
DOI:
https://doi.org/10.7439/ijap.v7i1.4550Keywords:
Antidiabetic, Antihypertensive, Hypolipedemic, Package insertAbstract
For estimation of Valsartan in pharmaceutical dosage form, a simple, accurate and precise area under curve spectrophotometric method was developed. The area under two points on the mixture spectra is directly proportional to the concentration of the component of interest is the AUC curve. The area selected for estimation of Valsartan was between 238.20 to 254.40 nm. The method represented regression coefficient (r2 = 0.996) at concentration rang 2-10 μg/ml. Estimation of the drugs was found up to 100 % representing the accuracy of the method. The recovery of the Valsartan was found up to 100 %. Validation of the proposed method was carried out for its accuracy, precision and specificity according to ICH Q2 (R1) guidelines. The developed methods can be successfully applied in routine work for the estimation of Valsartan in its pharmaceutical dosage form.
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