Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation

Authors

  • Audumbar Digambar Mali Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, India. Author
  • Ritesh Bathe Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, Author
  • Manojkumar Patil Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, Author
  • Ashpak Tamboli Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, Author

DOI:

https://doi.org/10.7439/ijasr.v1i6.2253

Keywords:

Levocetirizine, UV visible spectrophotometry, Accuracy, Precission, AUC, Method Validation

Abstract

Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 230 nm and the area under the curve method values measured at 227-234 nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25μg/ml (r

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Author Biography

  • Audumbar Digambar Mali, Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola- 413307, Solapur, Maharashtra, India.
    Pharmaceutics Department and First rank in solapur university,solapur.

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Published

30-07-2015

Issue

Section

Research Articles

How to Cite

1.
Mali AD, Bathe R, Patil M, Tamboli A. Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation. Int J of Adv in Sci Res [Internet]. 2015 Jul. 30 [cited 2024 Sep. 8];1(6):270-5. Available from: https://ssjournals.co.in/index.php/ijasr/article/view/2253

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