Estimation of ibuprofen and famotidine by (RP-HPLC)
Keywords:
IBU, FMT, RP-HPLCAbstract
A force degradation profile by RP-HPLC method was developed for Ibuprofen (IBU) & Famotidine (FMT) in combine tablet dosage form using Cosmosil RP-C18 (4.6 x 250mm, 5µm) in an gradient mode with mobile phase comprising of Methanol: Water (pH 2.5 using OPA) The flow rate was 0.7 mL/ min and effluent was monitored at 240 nm. The stress conditions selected on the basis of literature review and drug profile. The analysis of the marketed formulation shows the % RSD of 0.061 and 0.35 for IBU & FMT which fully agrees with system suitability. All the system suitability parameters were fully obeyed during generation of force degradation profile
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