A review: Cataract, a common ocular complication in Diabetes
DOI:
https://doi.org/10.7439/ijpr.v6i6.3286Keywords:
Diabetes mellitus, Cataract, Aldose Reductase, Polyol Pathway, SorbitolAbstract
With increasing prevalence of diabetes and its associated complications is a priority of health service globally. Diabetic ocular complications are most common in both type-1 and type-2 diabetes, considering the fifth most common cause of legal blindness. According to WHO, cataract is 33% of all type of visual impairment. Simply diabetic cataracts are characterized by cortical or posterior subcapsular opacities. Aldose reductase and polyol are responsible for diabetes ocular complications. Intracellular accumulation of sorbitol leads to osmotic stress resulting in the formation of lens opacities. Several clinical studies investigated the role of phacoemulsification surgery and its post surgery complications. Researcher are trying to develop aldose reductase inhibitors and antioxidents, may be effective treatment to prevent or cure diabetes cataract.
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