Study of gestational diabetes mellitus with special reference to oxygen free radicals

Authors

  • Shivaji Mane Additional Professor, Department of Biochemistry, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra-400022
  • Anisa B. Bebal Lab Technician, A/p Miraj Tal-Miraj, Dist. Sangli, Maharashtra-416410

Keywords:

Antioxidant, Gestational diabetes, Oxidative stress, Hemoglobin, Malondialdehyde, Superoxide dismutase, Ceruloplasmin

Abstract

Background: The exact pro-oxidant and antioxidant status in gestational diabetes is still not clear. Increased free radical activity in gestational diabetes can lead to a host of damaging and degenerative maternal and fetal complications. Hence the present study was undertaken to study effect of oxidative stress (lipid peroxidation) and antioxidants status in patients with gestational diabetes mellitus (GDM) and compare them with normal healthy pregnant controls of age and gestational age matched group.

Method: A total 68 samples as healthy pregnant controls (n=35) and GDM patients (n=33) were enrolled in the study. The biochemical parameters estimated in both the groups were fasting and post prandial blood glucose, glycosylated hemoglobin, malondialdehyde, superoxide dismutase, vitamin C and E, Uric acid, bilirubin, ceruloplasmin, copper and zinc.

Results: There was a significant increase in malondialdehyde, ceruloplasmin and uric acid in GDM maternal blood when compared to controls whereas superoxide dismutase exhibited a significant decrease in GDM cases. Also, we found highly significant decreased in plasma vitamins C, vitamin E and zinc while there was significantly increased in copper level in GDM cases as compared to controls.

Conclusion: Our findings showed that antioxidant capacity is lower in women with GDM, possibly related to lower intakes of vitamin E & C and zinc. Elevated glucose levels can induce oxidative stress in GDM mothers.

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Published

2013-12-30

Issue

Vol. 3 No. 4 (2013): Oct- Dec

Section

Research Articles

License

Copyright (c) 2013 International Journal of Pharmacological Research

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How to Cite

1.
Mane S, Bebal AB. Study of gestational diabetes mellitus with special reference to oxygen free radicals. Int J of Pharmc Res [Internet]. 2013 Dec. 30 [cited 2025 Mar. 14];3(4):82-6. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1203