Lipoprotein (a) In Type 2 Diabetes Mellitus: Relationship of Glycemic Control and LDL to HDL Ratio
Keywords:
Diabetes mellitus, Dyslipidemia, Lipoprotein, Hemoglobin, Glycemic control, TriglycerideAbstract
Background: Lp(a) evaluation may have the potential to improve cardiovascular risk prediction when used in addition to traditional lipid profiles. The present study was undertaken to evaluate the Lp(a) levels in healthy control and type 2 diabetic patients, also evaluate their association with the degree of glycemic control and LDL: HDL ratio.
Method: Fifty types 2 diabetic patients and age and sex-matched fifty non-diabetic controls were enrolled in the study. Fasting venous blood sample was collected from all the patients and analyzed for fasting blood glucose (FBS), glycated hemoglobin (HbA1c), lipid profile, and serum Lp(a). The Lp(a) levels were compared between two groups and association between the Lp(a) levels and LDL: HDL ratio was evaluated.
Results: Lp(a) levels were found to be significantly increased in the diabetic group (28.64±4.93) as compared to the control group (25.08±3.43). There was a significant elevation in the levels of BMI, FBG, total triglyceride, LDL: HDL ratio, TC/LDL ratio in the diabetic group as compared to the control group. Lp(a) levels showed an association with and degree of glycemic control in diabetic patients, but there was no association found between the level of Lp(a) and LDL: HDL ratio.
Conclusion: Type-2 diabetes mellitus is strongly associated with increased Lp (a) levels, and elevated Lp(a) levels reflect the glycemic status and are also independent of an increase in LDL: HDL ratio. Serum Lp (a) associated with lipid abnormalities high triglyceride, high LDL, TC/LDL ratio, and low HDL makes people with diabetes prone to coronary artery disease (CAD).
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