Amelioration of carbohydrate and fat metabolism by Houttuynia cordata and Hypochaeris radicata in alloxan-induced diabetic mice
Keywords:
Diabetes, glycolytic enzymes, Houttuynia cordata, Hypochaeris radicata, lipidsAbstract
Purpose: Houttuynia cordata and Hypochaeris radicata, local wild edibles were evaluated for their antidiabetic activity and effect on glycolytic enzymes. The activities of these plant extracts were compared to the anti-diabetic drug glibenclamide.
Methods: Mice were divided into control and test groups and were treated on every alternate day for a period of 14 days. Following the 14th day, serum and tissues were collected. For sub-acute studies and lipid profiling, serum was used while liver and skeletal muscle tissues were used for glycogen content estimation and glycolytic enzyme assays. The expression of glycolytic enzymes in normal, diabetic and diabetic treated mice was quantified using Kodak Digital Science 1 D Image Analysis Software, Version 3.0.
Results: The oral administration of extracts of Houttuynia cordata and Hypochaeris radicata lead to a significant blood glucose reduction. Houttuynia cordata and Hypochaeris radicata significantly lowered serum alanine transaminase (ALT) and aspartate transaminase (AST), triglyceride, total cholesterol, and low-density lipoprotein-cholesterol (LDL) levels of diabetic mice. Elevated high-density lipoprotein-cholesterol (HDL) was significantly increased upon administration of the extracts. Altered glycogen content seen in diabetics was also restored to near-normal levels. The plant extracts also enhanced the activity of the glycolytic enzymes.
Conclusion: From the present study, it can be concluded that Houttuynia cordata and Hypochaeris radicata have potent anti-diabetic properties.
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