Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Late Onset of Autoimmune Mediated Diabetes Mellitus (LADA) Case Report
DOI:
https://doi.org/10.7439/ijbr.v4i3.230Keywords:
Laparoscopy, Right Iliac Fossa pain, Appendicitis.Abstract
Latent autoimmune diabetes of adults (LADA) is a term describing patients with a type 2 diabetic phenotype combined with islet antibodies and slowly progressive ?-cell failure. Insulin therapy is the treatment of choice. We report a 36-years-male with LADA since 4 years, treated with insulin-secreting human adipose tissue derived mesenchymal stem cells (IS-ADMSC). He was glutamic acid decarboxylase antibody positive (26 IU/ml). He was on insulin, 65 International units (IU) and 4 OHG/day. Autologous IS-ADMSC + bone marrow-derived haematopoietic stem cells (HSC) were infused into subcutaneous, portal and thymic circulation with conditioning of bortezomibe and rabbit-antithymoglobulin. Over follow-up of 18 months he is doing well with sustained fall of glycosylated haemoglobin from 12.7 to 6.7% and with sustained 60% decreased insulin requirement with sustained control of the plasma blood glucose level. Thus long-term control of LADA with co-transplantation of IS-ADMSC+HSC can be achieved safely and effectively.Downloads
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Published
2013-04-01
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Case Report
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How to Cite
1.
Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Late Onset of Autoimmune Mediated Diabetes Mellitus (LADA) Case Report. Int Jour of Biomed Res [Internet]. 2013 Apr. 1 [cited 2024 Oct. 19];4(3):153-6. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/816