Antihypertensive activity of novel 1,4-dihydropyridine derivatives

Authors

  • Riazuddin Mohammed
  • Asma Samaunnisa Department of Pharmaceutical Chemistry, M.S. Ramaiah College of Pharmacy, Bangalore
  • Venkataramana C.H.S. Department of Pharmaceutical Chemistry, M.S. Ramaiah College of Pharmacy, Bangalore
  • Madhavan V Department of Pharmacognosy, M.S. Ramaiah College of Pharmacy, Bangalore

DOI:

https://doi.org/10.7439/ijbr.v5i5.619

Abstract

In the present work, screening for antihypertensive activity was carried out on a series of sixteen novel 2, 6-dimethyl-N 3 , N 5 -diphenyl-1, 4-dihydropyridine-3, 5-dicarbohydrazides (2A-2D) and 2,6-dimethyl-1,4-dihydropyridine-3,5-yl-bis[carbonyl-2- (phenyl)]pyrazolidine-3,5-diones] (3A-3D) derivatives. Structures of all the derivatives were previously confirmed by IR, 1 HNMR, mass and elemental analysis data.These derivatives contain central 1,4-dihydropyridine ring which is renowned for its calcium channel blocking activity. Antihypertensive activity was evaluated using tail cuff method in rats.Nifedipine was used as standard and 1% w/v sodium carboxy methyl cellulose suspension as control. Most of the compounds exhibited appreciable antihypertensive activity and are significant when compared with the standard. The Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Blood Pressure (MABP) were measured in both normotensive and hypertensive rats.

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Published

2014-05-30

Issue

Vol. 5 No. 5 (2014): May

Section

Original Research Articles

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How to Cite

1.
Antihypertensive activity of novel 1,4-dihydropyridine derivatives. Int Jour of Biomed Res [Internet]. 2014 May 30 [cited 2026 Mar. 8];5(5):322-6. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/1005