Comparison of Lignocaine and Ondensetron on Propofol injection pain
Keywords:
Propofol, Anesthesia, Lignocaine, Ondansetron, Pain, Visual analogue scoreAbstract
Background: Propofol is widely used for induction of anesthesia, although the pain during its injection remains a concern for all anesthesiologists. The present study was undertaken to evaluate and compare the effect of lignocaine and ondansetron on propofol injection pain.
Method:Total 200 ASA grade I and II patients who underwent general anesthesia for abdominal, urosurgery, plastic surgery and orthopedic elective surgical procedures were enrolled and divided into two equal groups.Group O received ondansetron 4mg IV and group L received lignocaine 40mg IV.Mid forearm was occluded manually before injection and released after 1 min and then propofol was injected over 5 s. Patients were observed and questioned 15 s later if they had pain in the arm and pain was scored on a four-point scale and visual analogue score scale.
Results: Both the groups were comparable in respect to demographic characteristics.The incidences of no pain on injection of propofol in ondensetron and lignocaine groups were 75% and 65% respectively, (p>0.05). The severity of propofol induced pain was not statistically different between lignocaine and ondansetron groups.There were no side effects noted in both the groups.
Conclusion:Intravenous pretreatment with lignocaine and ondansetron with manual venous occlusion reduces propofol injection pain in adult patients but ondansetron 4mg is aseffective as lignocaine 40mg. Hence, the choice of agent should be individualized with due consideration to the cost‑effectiveness and benefit to the patient.
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