DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASE LIGAND AS ANTIMALARIAL AGENTS.

Abstract

Schiff base ligand AA-1 , was derived from ethylenediamine and salicylaldehyde for the development of pharmaceuticals and it was followed by complexation of ligand with Ni (II) metal ion 2 . The data of elemental analyses, molar conductance, ¹H-NMR, IR, EI-MS was used for the corroboration of structural features of Schiff base AA1 and its complex AA2 along with the data obtained from single X-ray crystallography. The magnetic moment and UV spectral data was employed to proposed square planar geometry to the complex which was strongly supported by the Single-Crystal X-Ray diffraction studies. On the basis of conductivity data, it was suggested that the complex AA2 has non-electrolytic nature. The results of biological activities showed that the The most potent compound AA-5 showed inhibitory potency (IC50) of 2.1 mg/ml and 3mg/ml against chloroquine sensitive and chloroquine resistant strains respectively.The results of antibacterial activity showed that the ligand AA-1 exhibits moderately active while complex AA-2 exhibits good activity for chloroquine sanstive and resistant.