DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASE LIGAND AS ANTIMALARIAL AGENTS.
DOI:
https://doi.org/10.7439/ijbr.v4i3.241Abstract
Schiff base ligand AA-1 , was derived from ethylenediamine and salicylaldehyde for the development of pharmaceuticals and it was followed by complexation of ligand with Ni (II) metal ion 2 . The data of elemental analyses, molar conductance, 1H-NMR, IR, EI-MS was used for the corroboration of structural features of Schiff base AA1 and its complex AA2 along with the data obtained from single X-ray crystallography. The magnetic moment and UV spectral data was employed to proposed square planar geometry to the complex which was strongly supported by the Single-Crystal X-Ray diffraction studies. On the basis of conductivity data, it was suggested that the complex AA2 has non-electrolytic nature. The results of biological activities showed that the The most potent compound AA-5 showed inhibitory potency (IC50) of 2.1 mg/ml and 3mg/ml against chloroquine sensitive and chloroquine resistant strains respectively.The results of antibacterial activity showed that the ligand AA-1 exhibits moderately active while complex AA-2 exhibits good activity for chloroquine sanstive and resistant.Downloads
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Published
2013-04-01
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Original Research Articles
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DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SCHIFF BASE LIGAND AS ANTIMALARIAL AGENTS. Int Jour of Biomed Res [Internet]. 2013 Apr. 1 [cited 2024 Oct. 18];4(3):137-44. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/814