Histopathological spectrum of granulomatous disorders: a hospital based study at B.P. Koirala Institute of Health Sciences
DOI:
https://doi.org/10.7439/ijbr.v11i01.5343Keywords:
AFB(TB), Caseous necrosis, Granuloma, TuberculosisAbstract
Background: Granulomatous disorders comprise a large family sharing histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating usually as a result of the persistence of non-degradable product and of active cell mediated hypersensitivity. Incidence and prevalence of granulomatous disorder differs with geographic location. Histopathology along with special stains serves as gold standard tool for the diagnosis and classification of granulomatous disorders. The present study was done to investigate the histopathological spectrum on the patients of eastern part of Nepal.
Objectives: To study on histopathological spectrum of the granulomatous disorders at B.P. Koirala Institute of Health Sciences, Dharan.
Methods: Descriptive type of observational study was done on total 80 cases during the period of July 2017 to July 2018 in department of pathology of BPKIHS, Dharan.
Results: In present study, granulomatous disorders are common in third decade of life with male predominance (55%). Most commonly skin and subcutaneous tissue (40%) was the site affected by granulomatous reaction followed by lymph node (17.5%). Tuberculosis was found the most common etiology (38.75%) while Tuberculoid being the most common type of granuloma (60%). Ziehl Neelsen stain is helpful in diagnosis of tuberculosis (positive: 61.30%). Similarly Fite Faraco stain for leprosy is 37.5% (6/16). Non-caseating granulomas are more common (43/80, 53.67%).
Conclusion: Granulomatous lesion seems to be common in third decade of life with male predominance. Tuberculosis is the most common cause. The information is useful in management of granulomatous disorders and also for preventive measures.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.