Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Late Onset of Autoimmune Mediated Diabetes Mellitus (LADA) Case Report
DOI:
https://doi.org/10.7439/ijbr.v4i3.230Keywords:
Laparoscopy, Right Iliac Fossa pain, Appendicitis.Abstract
Latent autoimmune diabetes of adults (LADA) is a term describing patients with a type 2 diabetic phenotype combined with islet antibodies and slowly progressive ?-cell failure. Insulin therapy is the treatment of choice. We report a 36-years-male with LADA since 4 years, treated with insulin-secreting human adipose tissue derived mesenchymal stem cells (IS-ADMSC). He was glutamic acid decarboxylase antibody positive (26 IU/ml). He was on insulin, 65 International units (IU) and 4 OHG/day. Autologous IS-ADMSC + bone marrow-derived haematopoietic stem cells (HSC) were infused into subcutaneous, portal and thymic circulation with conditioning of bortezomibe and rabbit-antithymoglobulin. Over follow-up of 18 months he is doing well with sustained fall of glycosylated haemoglobin from 12.7 to 6.7% and with sustained 60% decreased insulin requirement with sustained control of the plasma blood glucose level. Thus long-term control of LADA with co-transplantation of IS-ADMSC+HSC can be achieved safely and effectively.Downloads
Download data is not yet available.
Downloads
Published
2013-04-01
Issue
Section
Case Report
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.
How to Cite
1.
Autologous Adipose Tissue Derived Insulin-Secreting Mesenchymal Stem Cell Transplantation In Late Onset of Autoimmune Mediated Diabetes Mellitus (LADA) Case Report. Int Jour of Biomed Res [Internet]. 2013 Apr. 1 [cited 2024 Oct. 18];4(3):153-6. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/816