Association of CYP2E1 genetic polymorphism with risk of Oral pre cancer and cancer in North Indian population

Authors

  • Kumud Nigam
  • Shalini Gupta
  • Syed Rizwan Hussain
  • Mohammad Kaleem Ahmad
  • Abbas Ali Mahdi
  • Anurag Tripathi

DOI:

https://doi.org/10.7439/ijbr.v7i1.2877

Abstract

Purpose: To evaluate the association of CYP2E1 promoter (-1091) C/T polymorphisms with the susceptibility of Oral pre cancer and cancer patients in North Indian population. Methods: A total 250 patients with oral pre cancer and cancer, 250 controls were genotypes for the CYP2E1 (C1091T) gene polymorphism. Genotypes were identified by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). Genotype frequencies were evaluated by Chi-square test and Odds ratio (OR) relative risk. Results: The average CYP2E1(C1091T) genotype frequencies of CC, CT and TT were calculated 80.80%, 5.20%, 14.00% in cases and 54.80%, 13.20% and 32.00% in healthy controls; respectively. Conclusion: We conclude that the CYP2E1 (C1091T) polymorphism was significantly associated in Oral pre cancer and cancer patients.

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Published

2016-01-30

Issue

Vol. 7 No. 1 (2016): Jan

Section

Original Research Articles

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How to Cite

1.
Association of CYP2E1 genetic polymorphism with risk of Oral pre cancer and cancer in North Indian population. Int Jour of Biomed Res [Internet]. 2016 Jan. 30 [cited 2024 Oct. 18];7(1):30-4. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/2877