Role of Serum Albumin in fracture healing

Authors

  • Manish Yadav
  • Ajai Singh
  • Sabir Ali Ph.D Scholar Dept. Of Orthopaedic Surgery K G Medical University
  • Nazia Rizivi
  • Syed Rizwan Hussain
  • Vineet Kumar

DOI:

https://doi.org/10.7439/ijbr.v6i7.2259

Abstract

Albumin is the most abundant plasma protein with molecular weight of 69 kd and it accounts for 55-60% measured in total serum protein, produced in liver. The multipotent progenitor cells of bone marrow differentiate into functional hepatocyte-like cells which expresses albumin. The 66kDa albumin protein is very prominent, and this protein component is present in the bone tissue as a major bone protein. The increase in IGF-I with fracture healing induce the production of albumin in the femoral-diaphyseal tissues and thus the osteoblastic proliferation takes place. The albumin also enhanced the bone calcium and DNA content that further promotes fracture healing, and its deficiency may be a significant determinant in healing process which may lead to fracture impairment. In this review we focused on the valuable significant role of albumin in fracture healing as well as the nonunion.

Downloads

Download data is not yet available.

Downloads

Published

2015-07-30

Issue

Vol. 6 No. 7 (2015): Jul

Section

Review Article

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • An author must submit Copyright form After acceptance of the article.

How to Cite

1.
Role of Serum Albumin in fracture healing. Int Jour of Biomed Res [Internet]. 2015 Jul. 30 [cited 2025 Mar. 12];6(7):452-5. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/2259