Awareness among mothers of Down syndrome children on the importance of folic acid consumption during pregnancy

Authors

  • Madawi Aldhwayan Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • May N Al-Muammar Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • Saada Alorf Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • Alyah Al-Moajel Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • Mona El-Shafie Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • Asim A Siddiqui Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,
  • Fozia Khan Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,

DOI:

https://doi.org/10.7439/ijbr.v6i11.2709

Abstract

Objective: The maternal use of folic acid supplementation particularly during the preconception period has been suggested to thwart Down syndrome, thus the awareness among the mothers of Down syndrome children regarding folic acid consumption and other factors was assessed in this study. Methods: In this population-based case study, mothers of children with Down syndrome [n=192] living in the city of Riyadh, Kingdom of Saudi Arabia, were enrolled through schools run by The Down syndrome society. Using a specially structured questionnaire that included questions on socio-demographic variables, womens knowledge about folic acid supplementation, and timing of supplementation was evaluated. Results: Analysis of data indicated children born to mothers who were 35 and above failed to follow recommended Folic acid supplementation. Around 70% percent of the DS mothers started taking supplementation after a confirmed pregnancy. Children were more likely to be born with DS if they were the 4th or more, child born to the same mother in the family. The rate was observed to be higher if they were born to mothers with even higher parity [>4]. Conclusion: The results of this study imply that folic acid supplementation is crucial for the prevention of Down syndrome before conception, as well as for the post-conception period in all women, especially for women who are 35 years and over and women with high parity.

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Author Biography

  • Fozia Khan, Community Health Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433,

    Community Health Sciences,

    Assistant Professor

References

Zigman WB. Atypical aging in down syndrome. Dev Disabil Res Rev 2013 ;18[1]:51-67.

Ragunath P, Abhinand P. Systems biological approach to investigate the lack of familial link between Down's Syndrome & Neural Tube Disorders. Bioinformation 2013;9[12]:610-6.

Samarkandy MM, Mohamed BA, Al-Hamdan AA. Nutritional assessment and obesity in Down syndrome children and their siblings in Saudi Arabia. Saudi Med J 2012;33[11]:1216-21.

Murthy SK, Malhotra AK, Mani S, Shara ME, Al-Rowaished EE, Naveed S, et al. Incidence of Down syndrome in Dubai, UAE. Med Princ Pract 2007;16[1]:25-8.

Niazi MA, al-Mazyad AS, al-Husain MA, al-Mofada SM, al-Zamil FA, Khashoggi TY, et al. Down's syndrome in Saudi Arabia: incidence and cytogenetics. Hum Hered 1995;45[2]:65-9.

Metneki J, Czeizel AE. Increasing total prevalence rate of cases with Down syndrome in Hungary. Eur J Epidemiol 2005;20[6]:525-35.

Biselli JM, Zampieri BL, Goloni-Bertollo EM, Haddad R, Fonseca MF, Eberlin MN, et al. Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome. Mol Biol Rep 2012;39[10]:9277-84.

Zampieri BL, Biselli JM, Goloni-Bertollo EM, Vannucchi H, Carvalho VM, Cordeiro JA, et al. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. Dis Markers 2012;32[2]:73-81.

Hook EB, Carothers AD, Hecht CA. Elevated maternal age-specific rates of Down syndrome liveborn offspring of women of Mexican and Central American origin in California. Prenat Diagn 1999;19[3]:245-51.

Doria-Rose VP, Kim HS, Augustine ET, Edwards KL. Parity and the risk of Down's syndrome. Am J Epidemiol 2003;15;158[6]:503-8.

Hollis ND, Allen EG, Oliver TR, Tinker SW, Druschel C, Hobbs CA, et al. Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project. Am J Med Genet A 2013;161A[3]:438-44.

Eskes TK. Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature. Eur J Obstet Gynecol Reprod Biol 2006;124[2]:130-3.

Coppede F. The complex relationship between folate/homocysteine metabolism and risk of Down syndrome. Mutat Res 2009;682[1]:54-70.

Patterson D. Folate metabolism and the risk of Down syndrome. Downs Syndr Res Pract 2008;12[2]:93-7.

Scala I, Granese B, Sellitto M, Salome S, Sammartino A, Pepe A, et al. Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring. Genet Med 2006;8[7]:409-16.

Zampieri BL, Biselli JM, Goloni-Bertollo EM, Vannucchi H, Carvalho VM, Cordeiro JA, et al. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. Dis Markers 2012;32[2]:73-81.

Cuckle HS. Primary prevention of Down's syndrome. Int J Med Sci 2005;2[3]:93-9.

Takamura N, Kondoh T, Ohgi S, Arisawa K, Mine M, Yamashita S, et al. Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. Eur J Nutr 2004;43[5]:285-7.

Hine RJ, James SJ. Down syndrome and folic acid update. J Am Diet Assoc 2000;100[9]:1004.

Al-Hossani H, Abouzeid H, Salah MM, Farag HM, Fawzy E. Knowledge and practices of pregnant women about folic acid in pregnancy in Abu Dhabi, United Arab Emirates. East Mediterr Health J 2010;16[4]:402-7.

Barkai G, Arbuzova S, Berkenstadt M, Heifetz S, Cuckle H. Frequency of Down's syndrome and neural-tube defects in the same family. Lancet 2003 Apr 19;361[9366]:1331-5.

Daltveit AK, Vollset SE, Lande B, Oien H. Changes in knowledge and attitudes of folate, and use of dietary supplements among women of reproductive age in Norway 1998-2000. Scand J Public Health 2004;32[4]:264-71.

Antonarakis SE, Petersen MB, McInnis MG, Adelsberger PA, Schinzel AA, Binkert F, et al. The meiotic stage of nondisjunction in trisomy 21: determination by using DNA polymorphisms. Am J Hum Genet 1992;50[3]:544-50.

Young SS, Eskenazi B, Marchetti FM, Block G, Wyrobek AJ. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod 2008;23[5]:1014-22.

Kovaleva NV, Tahmasebi-Hesari M, Verlinskaia DK. Grandmaternal age in children with Down syndrome in St. Petersburg. Tsitol Genet 2010;44[5]:47-53.

Agopian AJ, Marengo LK, Mitchell LE. Predictors of trisomy 21 in the offspring of older and younger women. Birth Defects Res A Clin Mol Teratol 2012;94[1]:31-5.

Czeizel AE, Puho E. Maternal use of nutritional supplements during the first month of pregnancy and decreased risk of Down's syndrome: case-control study. Nutrition 2005;21[6]:698-704.

Clementi M, Bianca S, Benedicenti F, Tenconi R. Down syndrome and parity. Community Genet 1999;2[1]:18-22.

Kallen K. Parity and Down syndrome. Am J Med Genet 1997;70[2]:196-201.

Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001;285[23]:2981-6.

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Published

2015-11-30

Issue

Vol. 6 No. 11 (2015): Nov

Section

Original Research Articles

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How to Cite

1.
Awareness among mothers of Down syndrome children on the importance of folic acid consumption during pregnancy. Int Jour of Biomed Res [Internet]. 2015 Nov. 30 [cited 2024 Oct. 18];6(11):903-8. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/2709

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