Effect of aqueous extracts of Curcuma longa and Syzygium aromaticum on some biological parameters of non-diabetic rats.
Keywords:
Curcuma longa, Syzygium aromaticum, cholesterol, triglycerides, toxicityAbstract
Introduction: Medicinal plants are used to cure various kinds of illnesses. This work aimed to evaluate the metabolic property of Curcuma longa and Syzygium aromaticum, two medicinal spices used by traditional therapists in Benin.
Study methods: The aqueous extracts of Curcuma longa rhizome and the Syzygium aromaticum seed were screened. Single dose 2000 mg/kg body weight acute oral toxicity tests were performed in female Wistar rats. Animal weight, serum creatinine, ALT transaminase and hemoglobin level were determined on day 0 and then on day 14. Histological sections were taken from the liver, kidneys and spleen. For the metabolic activity test, the extracts were administered to rats at a concentration of 300 mg/Kg of body weight for 21 consecutive days. The blood tests performed were blood sugar, triglycerides and cholesterol.
Results: The phytochemical screening revealed the presence of tannins, mucilages and flavonoids in both species. In terms of toxicity, there were no deaths. These extracts did not significantly change rat body weight, creatinine, ALT, hemoglobin, and did not alter the histology of the liver, kidneys, and spleen. Regarding metabolic activity, Curcuma longa extract significantly increased transiently total cholesterol and triglyceride.
Conclusion: Curcuma longa and Syzygium aromaticum were not acutely toxic and Curcuma longa transiently increased cholesterolemia and triglyceridemia. Any use of these plants should take into account their metabolic properties.
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