Association of vitamin D with insulin resistance in Type 2 Diabetic Mellitus patients

Abstract

Background : Several studies have reported a correlation between vitamin D deficiency and insulin resistance however few other studies proved vitamin D supplementation not improving the glucose homeostasis. The present study was aimed to find the association of vitaminD with insulin resistance and glycemic control and duration of diabetes in type2 diabetic patients with and without microvascular complications. Materials and methods : total 300 subjects in the age group of 35 70 years were divided into 3 groups.100 healthy subjects served as control group. 100 T2DM patients without microvascular complications chosen as study group-1 and 100 T2DM patients with microvascular complications were enrolled as study group-2. 25(OH)D3 was measured by chemiluminescence immunoassay, glycosylated hemoglobin (HbA1c) was measured by latex agglutination inhibition assay .Insulin resistance was estimated by HOMA-IR method. Results: 25(OH) D3 levels were lower in the T2DM patients with micro vascular complications than T2DM patients without microvascular complications and control groups, being 20.03 6.50ng/ml , 28.926.66ng/ml and 35.96 8.46ng/ml in the patients and control groups, respectively (p 0.001, Students t-test).Insulin resistance was significantly higher in study groups compared to control group (9.05 1.38 ,7.951.93,3.25 0.29) respectively. Conclusions : Vitamin D levels appeared to be lower in T2DM patients with microvascular complications than T2DM patients without microvascular complications and in the control group, vitamin D levels negatively correlated to insulin resistance, duration of diabetes and glycemic control.