Anti-anxiety activity of hydro alcoholic extract of Scoparia dulcis Linn. assessed using different experimental anxiety models In rodents

Authors

  • Arasan Elayaraja Department of Pharmacology, Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya [Deemed University], Enathur, Kanchipuram district, Tamil Nadu state
  • S. A. Rahaman Professor, Nirmala college of Pharmacy, Atmakur, Mangalagiri, Guntur district, Andhra Pradesh state.
  • Prem kumar P. Assistant Professor, SIMS College of Pharmaceutical Sciences, Guntur. Andhra Pradesh state
  • Phani Kumar K. Assitant Professor, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh

DOI:

https://doi.org/10.7439/ijpr.v5i3.1521

Abstract

Scoparia dulcis belonging to the family Scrophulariaceae is an valuable medicinal herb, had showed antiviral, antimalarial, anticancer and antidiabetic activities. The present study was aimed to investigate the anti-anxiety activity of crude ethanolic extract of S.dulcis L by various behavioural models. Preliminary phytochemical investigation revealed the presence of phenols and flavonoids. The extract at 100mg/kg and 200mg/kg was evaluated for anti anxiety activity by Open-field test [OFT], Elevated plus-maze test [EPM], Elevated Zero-maze test [EZM],, Social interaction test [SI] And Novelty induced suppressed feeling latency test [FL] and the results of behavioral tests indicated the dose dependent anti-anxiety activity of Scoparia dulcis which is comparable to standard. It was concluded that crude ethanolic extract showed anti anxiety activity.Further studies are needed to identify the anxiolytic mechanism(s) and the phytochemicals responsible for the observed anxiolytic effect of the hydroalcoholic extract of Scoparia dulcis.

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Published

2015-03-30

Issue

Vol. 5 No. 3 (2015): Mar

Section

Research Articles

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How to Cite

1.
Elayaraja A, Rahaman SA, P. P kumar, K. PK. Anti-anxiety activity of hydro alcoholic extract of Scoparia dulcis Linn. assessed using different experimental anxiety models In rodents. Int J of Pharmc Res [Internet]. 2015 Mar. 30 [cited 2024 Oct. 18];5(3):62-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1521

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