Anti-anxiety activity of hydro alcoholic extract of Scoparia dulcis Linn. assessed using different experimental anxiety models In rodents

Authors

  • Arasan Elayaraja Department of Pharmacology, Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya [Deemed University], Enathur, Kanchipuram district, Tamil Nadu state
  • S. A. Rahaman Professor, Nirmala college of Pharmacy, Atmakur, Mangalagiri, Guntur district, Andhra Pradesh state.
  • Prem kumar P. Assistant Professor, SIMS College of Pharmaceutical Sciences, Guntur. Andhra Pradesh state
  • Phani Kumar K. Assitant Professor, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh

DOI:

https://doi.org/10.7439/ijpr.v5i3.1521

Abstract

Scoparia dulcis belonging to the family Scrophulariaceae is an valuable medicinal herb, had showed antiviral, antimalarial, anticancer and antidiabetic activities. The present study was aimed to investigate the anti-anxiety activity of crude ethanolic extract of S.dulcis L by various behavioural models. Preliminary phytochemical investigation revealed the presence of phenols and flavonoids. The extract at 100mg/kg and 200mg/kg was evaluated for anti anxiety activity by Open-field test [OFT], Elevated plus-maze test [EPM], Elevated Zero-maze test [EZM],, Social interaction test [SI] And Novelty induced suppressed feeling latency test [FL] and the results of behavioral tests indicated the dose dependent anti-anxiety activity of Scoparia dulcis which is comparable to standard. It was concluded that crude ethanolic extract showed anti anxiety activity.Further studies are needed to identify the anxiolytic mechanism(s) and the phytochemicals responsible for the observed anxiolytic effect of the hydroalcoholic extract of Scoparia dulcis.

Downloads

Download data is not yet available.

Downloads

Published

2015-03-30

Issue

Vol. 5 No. 3 (2015): Mar

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
    4. Author must Submit Copyright form  After acceptance of Article

How to Cite

1.
Elayaraja A, Rahaman SA, P. P kumar, K. PK. Anti-anxiety activity of hydro alcoholic extract of Scoparia dulcis Linn. assessed using different experimental anxiety models In rodents. Int J of Pharmc Res [Internet]. 2015 Mar. 30 [cited 2025 Mar. 14];5(3):62-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1521
Crossref
Scopus
Google Scholar
Europe PMC