Lipid Profile of Patients with Thyroid Dysfunction in Ayurveda Hospital

Abstract

Background : Thyroid hormones play an indispensable role in various metabolic processes in the human body. Thyroid disorders other than iodine deficiency disorders in the form of thyroiditis, hypothyroidism or autoimmune thyroid dysfunctions are on rise. Objective : This study was done to study the prevalence and pattern of dyslipidemia in patients with thyroid dysfunction. Methods : It is a retrospective study based on the available biochemical data of 50 thyroid patients (33 females and 17 males) with age range of 26-68 years. Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) triiodothyronine (T₃), thyroxine (T₄) and thyroid stimulating hormone (TSH), were measured using standard assays procedures. Results: The results showed that 82% of the study population has hypothyroidism with the higher prevalence among females. The mean values of T₃, T₄ and TSH in patients with thyroid dysfunction were 0.8 0.05 ng/ml, 4.2 0.5 mg/dl and 9.45 1.2 mIU/ml, respectively. The mean values of TC, TG, HDL-C, LDL-C, and VLDL-C were 222.4 3.8 mg/dl, 180.3 8.2 mg/dl, 35.6 1.3 mg/dl, 151.6 6.2 mg/dl and 36.5 2.6 mg/dl respectively in patients with hypothyroidism. Hypothyroidism shows significant positive correlation with TC, TG and LDL. Results show that even a slight increase in serum TSH showed significant dyslipidemia. Conclusion : This study suggests that regular monitoring of lipid level in patients with thyroid dysfunction would be helpful in preventing cardiovascular diseases.