Assessment of factors affecting the platelet yield using continuous flow cell separator

Abstract

Background: The quality of single donor platelets (SDP) in terms of yield influences the platelet recovery in the recipient. Various donor factors such as predonation platelet count and hemoglobin concentration may affect platelet yield. The aim of present study was to assess the effect of various donor factors on platelet yield and effect of plateletpheresis on hematological values of donors. Materials and methods : A total of 171 plateletpheresis procedures were performed using continuous flow cell separator (Amicus Automated Blood Collection System version 2.52/3.1) were evaluated for platelet yield. The pre and post donation hematological values such as platelet count, hemoglobin (Hb) concentration, mean platelet volume (MPV) and platelet distribution width (PDW) were measured in all blood donors. Results : The mean platelet yield was 3.8 + 1.65 X 10¹¹ /unit. The platelet yield correlated positively (r = 0.446, p 0.001) with donor pre platelet count and negatively (r =- 0.004, p = 0.954) with donor pre-Hb. There was significant increase (p 0.001) in Hb concentration and platelet count decreased significantly (p 0.001) after each procedure. While, there was no significant decease in MPV and PDW after each procedure. Conclusion: All transfusion centers should have their own plateletpheresis donor data based on demographic and hematological characteristics of the donor population. This will ensure donor safety, product quality and an effective donor registry.