Association between androgen deficiency and metabolic syndrome in men with type 2 diabetes mellitus

Abstract

Objectives: This study aimed to- 1) assess the association of AD with the metabolic syndrome (MetS) in Saudi men with T2DM, 2) determine which component of the MetS that mostly associated with AD in these patients Methods: In this retrospective study sixty six Saudi men with T2DM were participated. Venous blood samples were collected in plain vacutainers from all the subjects. Serum glucose and lipid profile were measured using standard laboratory procedures. Serum total testosterone (TT) and sex hormone binding globulin (SHBG) were measured by ELISA. AD was defined according to Endocrine Society recommendation, while MetS was defined based on International Diabetes Federation criteria. Results: Patients showed marked dyslipidemia and significantly low TT and SHBG; 27.3% of patients have AD among which 43.5 % have MetS. Multivariate analysis revealed that obesity (OR 4.553, 95% CI: 1.093 - 18.957; P = 0.037) was the most component of the MetS that associated with AD. Total testosterone was negatively correlated to BMI (r=- 0.480, p=0.000), TG (r=- 0.397, p=0.004); but positively to SHBG (r= 0.706, p .001). Conclusion: Obesity as a core component of MetS is significantly associated with hypogonadism in T2DM. With the ongoing obesity epidemic, we believe that the control of body weight and encouragement of physical activity may impact on the reduction the consequences of AD among obese type 2 diabetics