Evaluation of cardiac specific Troponin T as a specific and sensitive biomarker over Creatine Kinase-MB in Acute Myocardial Infarction patients - A correlation analysis study

Authors

  • Sivaranjani N Department of Biochemistry, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur 621212, Tamil Nadu
  • Ravi Kiran VS Alluri Sitarama Raju Academy of Medical Sciences Eluru (ASRAM), Eluru. Andhra Pradesh
  • Venkataraman D. D. Department of Medicine, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur-621212, Tamil Nadu
  • Elango G. Department of Medicine, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur-621212, Tamil Nadu
  • S.Venkata Rao Department of Biochemistry, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur621212, Tamil Nadu

DOI:

https://doi.org/10.7439/ijbr.v5i2.501

Abstract

The purpose of the study was to evaluate, cTnT as a sensitive and specific diagnostic and prognostic biomarker for myocardial damage among, CKMB and LDH in AMI cases by correlation analysis study.A 50 patients of both sex (36-70 yrs.), with symptoms of acute myocardial infarction within 6 hours of onset were included in the study. Cardiac specific Troponin T, CKMB and LDH were measured at the time of admission. Descriptive statistics and Pearson correlation analysis were done. A statistically highly significant positive correlation was found between cTnT and CKMB (r (48) = 0.708, and p 0.0001), between cTnT and LDH (r (48) = 0.740 and p 0.0001) and between CKMB and LDH (r (48) = 0.531 and p 0.0001.We conclude and further we support the fact that cTnT estimation is sufficient as a, specific and sensitive biomarker for AMI diagnosis and prognosis over CKMB and LDH isoenzymes.

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Published

2014-02-19

Issue

Vol. 5 No. 2 (2014): Feb

Section

Original Research Articles

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How to Cite

1.
Evaluation of cardiac specific Troponin T as a specific and sensitive biomarker over Creatine Kinase-MB in Acute Myocardial Infarction patients - A correlation analysis study. Int Jour of Biomed Res [Internet]. 2014 Feb. 19 [cited 2026 Mar. 9];5(2):121-3. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/950