Robinsons cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardsons histologic grading

Authors

  • Junu Rajan Department of Pathology, Yenepoya Medical College, Deralakatte, Mangalore 575018
  • Pushalatha K Pai Department of Pathology, Yenepoya Medical College, Deralakatte, Mangalore 575018

DOI:

https://doi.org/10.7439/ijbr.v5i2.511

Abstract

Background: Carcinoma of the breast is one of the most common cancers in women. Fine needle aspiration cytology is the most common preoperative diagnostic modality. Preoperative grading of breast carcinomas would be desirable for the selection of patients for neoadjuvant therapy. This study is aimed at to grade the Fine Needle Aspiration Cytology (FNAC) smears of breast carcinomas and to correlate with histological grading. Methods: FNAC of 45 patients with breast cancer were studied. The cytological grading was evaluated using Robinson method (RGS) and the histological grading using Scarff-Bloom-Richardson grading system (SBR). Statistical analysis was performed using the SSPS statistical software package (SSPS) (Chicago, Illinois, USA).Correlation was established using Spearman correlation coefficient. Results: There were 45 cases and the age of the patients ranged from 26 years to 75 years with a mean age of 53.6 years. Univariate analysis showed strong correlation. By doing multiple regression analysis of cytologic features revealed that cell size, uniformity and nucleoli were the most potent features. There was a significant association (P 0.000) between the grades assigned to cytologic and histologic specimens. Conclusion:
  1. Cytological grade could be used to predict histological grade as significant relationship exist between grades assigned to cytology and histology specimens
    1. Cytologic grade may provide relevant information on the aggressiveness of ductal breast carcinoma and could be a useful parameter to take into consideration while selecting cases for neoadjuvant therapy

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Published

2014-02-28

Issue

Vol. 5 No. 2 (2014): Feb

Section

Original Research Articles

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How to Cite

1.
Robinsons cytological grading of breast carcinoma and its correlation with Scarff Bloom Richardsons histologic grading. Int Jour of Biomed Res [Internet]. 2014 Feb. 28 [cited 2025 Mar. 13];5(2):105-9. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/946