Waldenstroms Macroglobulinemia - a coincidental finding in a case of carcinoma of buccal mucosa

Authors

  • Mahjabeen Salma Dr. VRK Women's Medical College, Aziznagar, Rangareddy district, Andhra Pradesh-500075.
  • Sudha Madhuri Consultant Pathologist, Yashoda Hospitals, Somajiguda, Hyderabad
  • Nandish Kumar S. J. Consultant Oncologist, Yashoda Hospitals, Somajiguda, Hyderabad
  • Karimuddin Abdullah Shaik 3rd year MBBS student, Shadan Institute of Medical Sciences, Peerancheru, Hyderabad

DOI:

https://doi.org/10.7439/ijbr.v5i1.401

Abstract

Waldenstr's Macroglobulinemia (WM) is a clonal disorder of small lymphocytes that show maturation to plasma cells synthesizing IgM. It is the biological activity of IgM protein that determines most of the clinical manifestations of the disease. WM most closely corresponds to lymphoplasmacytic lymphoma or immunocytoma of the REAL classification of lymphoma. Here, we report a case of a 50 year old male with squamous cell carcinoma of buccal mucosa. On routine investigations we found autoagglutination of RBCs; on workup with this feature we had suspicion of Waldenstr's Macroglobulinemia. The diagnosis of WM was established after cytomorphology and immunohistochemistry (IHC) analysis of the bone marrow which revealed the presence of a lymphoid/lymphoplasmacytoid-like bone marrow infiltrate along with an elevated serum IgM level. Waldenstr's Macroglobulinemia and its co-existence with autoimmune diseases and non hematological malignancies has already been described in the literature, but the present case was asymptomatic for WM with carcinoma of buccal mucosa, which is the first case reported so far.

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Author Biography

  • Mahjabeen Salma, Dr. VRK Women's Medical College, Aziznagar, Rangareddy district, Andhra Pradesh-500075.
    Department Of Pathology, Associate Professor.

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Published

2014-01-30

Issue

Vol. 5 No. 1 (2014): Jan

Section

Case Report

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How to Cite

1.
Waldenstroms Macroglobulinemia - a coincidental finding in a case of carcinoma of buccal mucosa. Int Jour of Biomed Res [Internet]. 2014 Jan. 30 [cited 2026 Mar. 8];5(1):56-8. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/932