A Clinicopathological audit of thyroid malignancies A 2 year study
DOI:
https://doi.org/10.7439/ijbr.v5i1.482Keywords:
Primary thyroid malignancyAbstract
Thyroid cancer is the commonest of all endocrine malignancies with annual incidence of 0.5-10 cases /100000 population constituting 1 % of all malignancies .Most present as solitary thyroid nodules clinically indistinguishable from benign lesions posing great diagnostic trial . Histopathology plays a major role in diagnosis. Aim : The objective of this study is to determine the overall incidence ,frequency of variants and analyse with clinical presentation. Material /Methods : All specimens of thyroid were grossed and processed methodically. Diagnosed cases of primary malignant neoplasms were analysed clinicopathologically. Results - Papillary carcinoma formed the majority (83%) with 63% classical type . Solid and tall cell variants (4%) behaved in aggressive manner. Medullary and follicular carcinomas were rare (12%). 66% cases presented with solitary nodule. 71% comprised of less than 2cm in size. 22% of cases presented with metastases in lymphnode, liver, lung .Three cases of Non-Hodgkins lymphoma and mesenchymal sarcoma ,confirmed by immunohistochemistry marker study ,were the least common(6%). Fourteen cases of papillary carcinoma and three medullary carcinomas were discerned in the background of multinodular goitre (28%). Likewise,three papillary carcinomas and a lymphoma occured in Hashimotos thyroiditis (7%). Conclusion - 1. Papillary carcinoma is most common type with predominantly classical variant having presentation at any age also with secondaries. 2. Papillary carcinoma can be aggressive in solid and tall cell variant. 3. Size is not a criterion for malignancy. 4. Majority show female preponderance. 5. Lymphomas and sarcomas are not uncommon.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2014 International Journal of Biomedical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.