Synthesis, characterization and antimicrobial activity of novel 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives

Authors

  • Deepak Kumar Basedia T.I.T.College of Pharmacy, Anand Nagar, BHEL, Bhopal (MP)
  • Birendra Shrivastava School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan
  • B. K. Dubey T.I.T. College of Pharmacy, Anand Nagar, BHEL, Bhopal, M.P.
  • Pankaj Sharma School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan

DOI:

https://doi.org/10.7439/ijbr.v5i1.434

Keywords:

misoprostol, induction of labour

Abstract

Synthesized fused heterocyclic compounds 1,3,4-oxadiazolo[3,2-a]-s-triazine derivatives based on microwave mediate multi-component reaction (MCRs). In general, multi-component reactions (MCRs) are economically and environmentally very advantageous because multi-step syntheses produce considerable amounts of waste mainly due to complex isolation procedures often involving expensive, toxic and hazardous solvents after each step. Simpler procedures, equipment, lower costs, time and energy and environmentally friendly. All the synthesized compounds were characterized using physical and spectral analysis. Antimicrobial activity of synthesized compounds was carried out by cup-plate method. All the synthesized compounds show a moderate biological activity. The compound 1c, 1e, 1i, 2b, 2d, 2i and 1b, 1e, 1j, 2a, 2d show better significant antibacterial and antifungal activity respectively.

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Published

2014-01-30

Issue

Vol. 5 No. 1 (2014): Jan

Section

Original Research Articles

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How to Cite

1.
Synthesis, characterization and antimicrobial activity of novel 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-[3,2-a]-1,3,5-triazine derivatives. Int Jour of Biomed Res [Internet]. 2014 Jan. 30 [cited 2026 Mar. 9];5(1):13-8. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/920