Synthesis, characterization and biological evaluation of some novel 9-benzooxazol-4-yl-3,4-diphenyl-1-oxa-6-thia-2,4,9-triaza-spiro[4.4] non-2-en-8-ones

Authors

  • Raghu Vardhan Reddy Mekala Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh 506-009
  • Sunil Vodela Talla Padmavathi College of Engineering, Kazipet, Warangal, Andhra Pradesh 506-003
  • Hemalatha Gadegoni University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh 506-009

DOI:

https://doi.org/10.7439/ijbr.v5i1.395

Abstract

A series of various novel 4-benzooxazol-4-yl-9-phenyl-1,6-dithia-4,9-diaza-spiro[4.4]nonane-3,8-diones (5a-e) and 9-benzooxazol-4-yl-3,4-diphenyl-1-oxa-6-thia-2,4,9-triaza-spiro[4.4]non-2-en-8-ones (6a-e) were synthesized in good yields by using 4-nitro-1 H -benzooxazole (1) as starting material and 4-amino-1 H -benzooxazole (2) , N -benzooxazol-4-yl-2-chloro-acetamide (3) and 3-benzooxazol-4-yl-2-phenylimino-thiazolidin-4-ones (4a-e) as intermediates. After structural confirmation, the title compounds were screened for their antimicrobial and anti-inflammatory activity.

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Published

2013-01-31

Issue

Vol. 5 No. 1 (2014): Jan

Section

Original Research Articles

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How to Cite

1.
Synthesis, characterization and biological evaluation of some novel 9-benzooxazol-4-yl-3,4-diphenyl-1-oxa-6-thia-2,4,9-triaza-spiro[4.4] non-2-en-8-ones. Int Jour of Biomed Res [Internet]. 2013 Jan. 31 [cited 2026 Mar. 8];5(1):05-12. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/919