Quantitative analysis of Serum Uric Acid and C-reactive protein level in North Indian Pre-diabetic and Diabetic subjects

Abstract

Background: Diabetes is a metabolic disorder with inappropriate hyperglycemia either due to an absolute or relative deficiency of insulin secretion or reduction in the biologic effectiveness of insulin or both. It is also associated with disturbances concerned with protein, carbohydrate, and lipid metabolism. In the present study, we have estimated the Level of serum Uric Acid and C-reactive protein in pre-diabetic and diabetic patients from northern India. Method: This is a Prospective observational study and total 79 subjects were enrolled on the basis of American Diabetic Association (ADA) Guidelines 2010. Out of 79 subjects, 16 subjects were Pre-Diabetic and 63 subjects were Diabetic. Serum uric acid was estimated by using MERK Kit with the help of semi-automated analyzer. Estimation of C-reactive protein was done by the commercially available Kit with the help of MISPA instrument base on nephelometry method. Result: The Serum uric acid level of Diabetic group was (p 0.001) lower as compared to Pre diabetic group, but we did not find any significant difference of C - reactive protein level between the two groups and the diagnostic accuracy of Serum uric acid was significantly higher than the C - reactive protein level. Conclusion: The present study suggests that that low Serum uric acid level and high CRP levels may play a significant role in progression of diabetes.