Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Abstract

Background: Carcinoma of the gallbladder is a highly fatal disease with late diagnosis, limited treatment options and deprived prognosis. It is the fifth most common cancer of gastrointestinal tract and the most common cause of death from biliary malignancies. In postmenopausal women, hormone replacement therapy significantly increases the risk of gallbladder diseases. Gallstones and gallbladder cancer predominate in females and are associated with obesity and multiple pregnancies. In the present study, we have estimated the Level of Estradiol and Lipid profile in different study groups and healthy controls from northern India. Results: The estradiol level was significantly (p 0.001) higher among patients with gall bladder cancer and stone both, gallbladder stone, gall bladder cancer compared with controls. The lipid profile and estradiol levels were almost similar among males in both study and control group while significantly different among females. Conclusions: These results indicate that the female gender is strongly associated with disease and the possible reason is increased level of total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein and decreased level of high density lipoprotein, and also the higher level of estrogen.