RENAL FUNCTIONS IN PREGNANCY INDUCED HYPERTENSION, PREECLAMPSIA, AND ECLAMPSIA

Abstract

Background and Objective: A Hypertensive disorder of pregnancy is an important cause of maternal mortality and Eclamptic conditions including renal dysfunctions. The present study is aimed at evaluating and comparing the urinary protein, creatinine and their ratio during Pregnancy Induced Hypertension, Preeclampsia and Eclampsia. Materials and Methods: Defined groups of Pregnancy Induced Hypertension, Pre-eclampsia and eclampsia patients were selected with written informed consent with fifty subjects in each group. The urine was collected and used for the estimation the urinary protein, creatinine and their ratio in normal and experimental groups. The data were expressed as Mean SD. Comparison between patients and controls was performed using unpaired rest. P value less than 0.05 was considered significant. Results: The mean SBP and DBP was significantly higher (p 0.001) in all the experimental groups as compared to normal subjects. The mean urinary protein and creatinine in PIH cases, Preeclampsia and Eclampsia was significantly higher (p 0.001) as compared to normal group. The protein creatinine ratio was also significantly higher (p 0.001) in all the experimental groups as compared to normal subjects. Conclusion: The significant elevation in urinary protein, creatinine and their ratio in the present study suggesting the fact that, the anti-angiogenic factors emanating from the placenta in PIH, Preeclampsia and Eclampsia contribute to glomerular endotheliosis, proteinuria, and hypertension.