CIRCULATING CONCENTRATIONS OF IL-2, IL-6, TNF-ALPHA AND ENDOTOXIN IN PATIENTS OF CARCINOMA GALL BLADDER

Authors

  • Induja Awasthi PhD Scholar, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.
  • Lav Kumar Kacker Ex- Professor, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.

DOI:

https://doi.org/10.7439/ijbr.v3i8.671

Keywords:

Cost analysis, cost per test

Abstract

Introduction: Gallbladder Cancer represents the most common and aggressive type among the biliary tree cancers (BTCs). Carcinoma Gallbladder has an unusual geographic distribution. The highest incidence of carcinoma of gallbladder is in Chileans, American Indians, and in parts of North India. Objective: The present study was designed to characterise the circulating concentrations of endotoxin and different inflammatory mediators in patients with Carcinoma Gall bladder. Methods and Material: One hundred twenty eight Carcinoma Gall bladder patients were included in the study. Enzyme-linked immunosorbent assay was used for determining the circulating concentrations of Interleukin-2 (IL-2), Interleukin -6 (IL-6), Tumor Necrosis Factor-? (TNF-?)and Endotoxins in human serum. A cross sectional trial was performed. Results: The mean age of the patients was 50.8612.6 years. The mean duration of jaundice was since last 74.9150.0 days. Fifty five percent patients had cholelithiasis association with Carcinoma Gall bladder. The mean Body Mass Index (BMI) of Carcinoma Gall bladder patients were 18.332.8. The mean circulating concentrations of IL-2 were 33.3156.6 pg/ml, IL-6 were 167.16216.4 pg/ml, TNF-? were 56.0056.7 pg/ml and endotoxin were 0.660.2 EU/ml. Conclusions: Mean circulating concentrations of IL-2 and TNF-? were lower and mean circulating concentrations of IL-6 were higher than the previous studies. The mean circulating concentrations of endotoxin were within the normal limits. Which concludes that cytokines may participate in gallbladder carcinogenesis and the study provides evidence for a strong link between chronic inflammation and Carcinoma Gall bladder.

Downloads

Download data is not yet available.

Author Biographies

  • Induja Awasthi, PhD Scholar, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.
    PhD Scholar,Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.
  • Lav Kumar Kacker, Ex- Professor, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.
    Ex- Professor, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.

Downloads

Published

2012-09-01

Issue

Vol. 3 No. 8 (2012): Aug

Section

Original Research Articles

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • An author must submit Copyright form After acceptance of the article.

How to Cite

1.
CIRCULATING CONCENTRATIONS OF IL-2, IL-6, TNF-ALPHA AND ENDOTOXIN IN PATIENTS OF CARCINOMA GALL BLADDER. Int Jour of Biomed Res [Internet]. 2012 Sep. 1 [cited 2026 Mar. 9];3(8):366-70. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/765