GREEN SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME MANNICH BASES OF 1, 4 DIHYDROPYRIDINE COMPOUNDS

Authors

  • Pravin Jadhav Department of Pharmaceutical chemistry, Modern college of Pharmacy (Ladies), Moshi, Pune- 412105, Maharashtra.
  • Rohini R. Pujari Department of Pharmaceutical chemistry, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune- 411018 Maharashtra.
  • N. R. Chatterjee Department of Pharmaceutical chemistry, Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune- 411018 Maharashtra.

DOI:

https://doi.org/10.7439/ijbr.v3i7.132

Abstract

Some new Mannich Bases of 1, 4 Dihydropyridine derivatives were synthesised by reaction of 1, 4 Dihydropyridine derivatives formaldehyde (HCHO) and secondary amines (e.g. morpholine, 1-methyl piperazine) in 1:1 ratio under acidic condition in presence of trace HCl. The compounds synthesised were identified by UV, 1H NMR, and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their antihypertensive activity by against DOCA salt induced hypertension.

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Published

2012-08-01

Issue

Vol. 3 No. 7 (2012): Jul

Section

Original Research Articles

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How to Cite

1.
GREEN SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME MANNICH BASES OF 1, 4 DIHYDROPYRIDINE COMPOUNDS. Int Jour of Biomed Res [Internet]. 2012 Aug. 1 [cited 2024 Oct. 19];3(7):334-42. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/760

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