Study of glutathione metabolism oxidative stress and the effect of vitamin E supplementation in COPD .

Authors

  • Anita Madhav Raut Maharashtra University of health sciences

DOI:

https://doi.org/10.7439/ijbr.v3i7.178

Abstract

Oxidative stress has bseen recognized as a central feature of smoke induced chronic obstructive pulmonary disease (COPD). Imbalance between oxidant and glutathione redox cycle is also an established fact in these patients. 60 patients with chronic bronchitis and 60 with Emphysema were include in the study. Their base line clinical examination , malondialdehyde (MDA), alpha tochopherol and glutathione peroxidase (GPx) and glutathione reductase levels were measured. 100 healthy non-smokers were served as controls. All the above parameters were repeated after 8 weeks of supplementation with 400 IU of vitamin E twice daily with regular treatment and without regular treatment. The mean malondialdehyde levels in the patients at base line were high (P 0.001) than Controls . Plasma alpha-tocopherol , glutathione peroxidase, glutathione reductase

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Author Biography

  • Anita Madhav Raut, Maharashtra University of health sciences
    Biochemistry Department

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Published

2012-08-01

Issue

Vol. 3 No. 7 (2012): Jul

Section

Original Research Articles

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How to Cite

1.
Study of glutathione metabolism oxidative stress and the effect of vitamin E supplementation in COPD . Int Jour of Biomed Res [Internet]. 2012 Aug. 1 [cited 2025 Mar. 14];3(7):322-6. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/757