Association of blood inflammatory markers with ankle brachial pressure index in patients with type 2 diabetes mellitus

Authors

  • Rama Prakasha S Assistant Professor, Dept. of General Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India. Pin-575018
  • Rakshatha Nayak Final year MBBS student; K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India. Pin-575018
  • Suchetha Kumari N Professor, Department of Biochemistry, K.S. Hegde Medical Academy, Deralakatte, Mangalore 575 018
  • Ganesh Kumar S M.D. Assistant Professor, Dept. of Preventive and Social Medicine,JIPMER, Puducherry.

DOI:

https://doi.org/10.7439/ijbr.v3i7.541

Abstract

Background: A significant positive correlation exists between the inflammatory markers, hs-CRP (C reactive protein) and ferritin and the parameters of dyslipidemia in patients with type 2 diabetes. Not much is known regarding diabetes, inflammation and vasculopathy especially in relation to ferritin from this region. Aim: To correlate serum CRP and ferritin levels with Ankle Brachial Pressure Index (ABPI) in type 2 diabetic patients. Methodology: Descriptive observational study of 50 diabetic patients done at K. S. Hegde Medical College Hospital, Mangalore, Karnataka, India. Results: ABPI correlated negatively with serum ferritin values; with a Pearson correlation value and p value of - 0.187 and 0.194 respectively. Also, ABPI negatively correlated with CRP, and this correlation was statistically significant (-0.382, P=0.006). Conclusion: Measurement of ABPI is a simple and clinically useful tool in identifying peripheral arterial disease in patients at risk of accelerated atherosclerosis. ABPI negatively correlated with serum ferritin and CRP levels in this study, though the association with ferritin was statistically not significant. Further large scale studies are needed to elucidate the association of ferritin as a nonconventional risk factor of atherosclerosis and PAD in type 2 diabetes mellitus.

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Author Biographies

  • Rama Prakasha S, Assistant Professor, Dept. of General Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India. Pin-575018
    Assistant Professor, Dept. of General Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India. Pin-575018
  • Suchetha Kumari N, Professor, Department of Biochemistry, K.S. Hegde Medical Academy, Deralakatte, Mangalore 575 018
    Department of Biochemistry,K.S. Hegde Medical AcademyDeralakatte, Mangalore – 575 018 INDIA.
  • Ganesh Kumar S, M.D. Assistant Professor, Dept. of Preventive and Social Medicine,JIPMER, Puducherry.
    MD; Dept. of preventive and social Medicine; JIPMER, Puducherry, India

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Published

2012-08-01

Issue

Vol. 3 No. 7 (2012): Jul

Section

Original Research Articles

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How to Cite

1.
Association of blood inflammatory markers with ankle brachial pressure index in patients with type 2 diabetes mellitus. Int Jour of Biomed Res [Internet]. 2012 Aug. 1 [cited 2024 Oct. 18];3(7):317-21. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/756