HEPATO-PROTECTIVE ACTIVITY OF STEM BARK EXTRACTS OF FICUS RELIGIOSA LINN IN RATS

Authors

  • Kavita Suryawanshi Department of Pharmacology, VNS Institute of Pharmacy, Bhopal (M.P.)
  • Sanjay Khakre Truba college of Pharmacy, Bhopal (M.P.)
  • Ashish Chourasia Department of Pharmacology, VNS Institute of Pharmacy, Bhopal (M.P.)
  • P. K. Chaurasiya Department of Pharmacology, VNS Institute of Pharmacy, Bhopal (M.P.)
  • R. S. Pawar Department of Pharmacology, VNS Institute of Pharmacy, Bhopal (M.P.)
  • Deenanath Jhade School of Pharmacy, Chouksey Engg. College, Bilaspur (C.G.)

DOI:

https://doi.org/10.7439/ijbr.v2i8.128

Keywords:

Anaemia, Haemoglobin, Maternal outcome, Perinatal outcome

Abstract

Hepatoprotective activity of stem bark extracts of Ficus religiosa Linn. (Moraceae) investigated against Paracetamol (2g/kg) induced hepatotoxicity in rats. Stem bark powder of Ficus religiosa was successively extracted with different solvents by soxhlet apparatus. The extracts of F. religiosa stem bark were administered in a dose of 200 mg/kg orally. Silymarin (100mg/kg) was used as standard drug. The hepatoprotective effect of these extracts was evaluated by the assessment of biochemical parameter such as SGOT, SGPT, ALP, Total bilirubin, and histopathological studies of the liver. The preliminary Phytochemical screening of F. religiosa revealed the presence of Triterpenoids, Flavonoids, Saponins, Steroids, Tannins and Phenolic compounds, Carbohydrate, Protein. The treatment with extract of F. religiosa showed significant reduction of Paracetamol induced elevated serum enzyme levels. The present study shows that extract of Ficus religiosa L. has significant hepatoprotective activity and methanolic extract was found to exhibit greater hepatoprotective activity than the other extract.

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Published

2011-09-01

Issue

Vol. 2 No. 8 (2011): Aug

Section

Original Research Articles

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Copyright (c) 2011 International Journal of Biomedical Research

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How to Cite

1.
HEPATO-PROTECTIVE ACTIVITY OF STEM BARK EXTRACTS OF FICUS RELIGIOSA LINN IN RATS. Int Jour of Biomed Res [Internet]. 2011 Sep. 1 [cited 2026 Mar. 9];2(8):466-75. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/676