PREPARATION AND EVALUATION OF TRANSDERMAL PATCH OF DESLORATADINE

Abstract

Transdermal patches are innovative drug delivery systems and can be used for achieving efficient systemic effect by passing hepatic first-pass metabolism and increasing the fraction absorbed. The transdermal therapeutic system provide for continuous drug release through intact skin into the systemic blood stream during a prolong time at a preset rate. Desloratadine, on oral administration, may cause many adverse effects such as headache, fatigue, dryness of mouth, nose or throat, nausea, vomiting, drowsiness etc. and it is also poorly water soluble, so it shows dissolution rate limited absorption. To avoid these problems, the matrix type transdermal patches of Desloratadine are prepared by solvent casting technique on mercury substrate. For this purpose transdermal patches were prepared by using film-forming polymer such as HPMC 6 cps with PG as a plasticzer by solvent evaporation technique. The patches produced were found to be satisfactory in terms of physicochemical properties like appearance, thickness, weight variation, folding endurance, moisture content, tensile strength, percent elongation at break and percent drug content. Prepared patches exhibited zero order kinetics permeation of the drug from the patches was governed by a diffusion mechanism. Drug-excipient interaction studies will be carried out using FTIR technique. The optimized batch (F7- HPMC 6 cps 6% and PG 3%) was subjected to stability studies for a period of 1 month. The results indicated that there was no appreciable change in the values of in vitro diffusion profile.