TLR4 AND PI3K/AKT PATHWAY ACTIVATION: NEW APPROACH FOR CANCER DETECTION

Abstract

Cancer is not just one disease, but a large group of almost 100 diseases. Its two main characteristics are uncontrolled growth of the cells in the human body and the ability of these cells to move about from the original site and extend to distant sites. If the spread is not controlled, cancer can result in death. What difficult is its detection in our body and if it can be detected earlier there is possible treatment with the help of complete removal of tumor. On the other side toll like receptors (TLRs) are family of receptor responsible for detection of pathogen associated molecular patterns (PAMPs) and result in induction of immune response. In various studies over-expression of Akt (serine/threonine protein kinase) phosphorylation has been found in various kinds of cancerous cells when encounter of lipopolysaccharide (LPS) with TLR4 happened. We can identify these changes and move further toward the possible detection. Over-expression of Akt phosphorylation may have possible role for cancer detection in future.