ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE

Authors

  • Y VenuGopal St.Peter Institute of Pharmaceutical sciences, Vidya Nagar, Warangal, A.P
  • Ravindranath A University College of Technology, Osmania University, Hyderabad A.P,
  • Kalpana G St.Peter Institute of Pharmaceutical sciences, Vidya Nagar, Warangal, A.P
  • Prabhaker Reddy.V St.Peter Institute of Pharmaceutical sciences, Vidya Nagar, Warangal, A.P

DOI:

https://doi.org/10.7439/ijbr.v2i4.103

Keywords:

Intramedullary nail, tibia, surgical implant, clinical anatomy

Abstract

The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor activity in EAC-bearing mice.

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Published

2011-05-01

Issue

Vol. 2 No. 4 (2011): Apr

Section

Original Research Articles

License

Copyright (c) 2011 International Journal of Biomedical Research

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How to Cite

1.
ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE. Int Jour of Biomed Res [Internet]. 2011 May 1 [cited 2026 Mar. 9];2(4):264-71. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/656