ROLE OF GLUTAMINE SUPPLEMENTATION ON IMPROVING THE NUTRITIONAL, FUNCTIONAL AND IMMUNOLOGICAL STATUS OF MALIGNANT OBSTRUCTIVE JAUNDICE PATIENTS AT A TERTIARY CARE CENTRE.
DOI:
https://doi.org/10.7439/ijbr.v2i3.95Keywords:
Respiratory Distress, early neonatal period, Cesarean sectionAbstract
Introduction: Incidence of carcinoma gall bladder in India ranges from 1.01/100000 for males to 10.1/100000 for females. Glutamine decreases intestinal permeability, maintain intestinal barrier and attenuate systemic inflammatory response.
Objectives: Assessment of Nutritional status, functional status and mortality in Glutamine supplemented (Gp. A) /Non- supplemented (Gp. B) Malignant Obstructive Jaundice (MOJ) patients in which endoscopic drainage /surgery was impossible.
Methods: Fifty patients Gp.A-25 and Gp.B-25, were included in the study. Supplementation was 50 ml (20g)/day intravenously to the patients for 3 days and 30g/day orally for 4 days. BMI, Karnofsky Score and mortality were assessed on 42nd day.
Results: Gp. A mean BMI was 16.32+ 2.64 on admission and 16.37+ 3.42 on 42nd day. In Gp.B mean BMI on admission was 18.15+ 1.27 which improved to 21.35+ 2.53 on 42nd day. In Gp. A mean Karnofsky score was 55.60+ 20.02 on admission and 21.20+ 25.71 on 42nd day. In Gp. B mean Karnofsky score on admission was 60.00+ 19.58 and 24.00+ 33.54 on 42nd day. The mean IL-2 Level in Gp.A was 13.93+ 26.80 pg/ml on admission and 81.30+ 79.46 pg/ml on 42nd day. The mean IL-2 Level in Gp.B was 9.07+ 26.93 pg/ml on admission which reduced to 8.27+ 15.21 pg/ml on 42nd day. IL-6 Level in Gp.A was 79.43+ 96.83pg/ml on admission and173.10+ 217.94pg/ml on 42nd day. IL-6 Level in Gp.B was 390.06+ 345.22 pg/ml on admission which reduced to 230.71+ 201.65pg/ml on 42nd day. TNF-α Level in Gp.A was 59.53+ 56.63pg/ml on admission
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