ANTIULCER ACTIVITY OF THE METHANOLIC EXTRACT OF SESBANIA GRAINDIFLORA

Authors

  • Bhushan Hatwar Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh
  • Arunabha Mallik Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh
  • Satish Nayak Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh

DOI:

https://doi.org/10.7439/ijbr.v1i4.70

Keywords:

Sesbania graindiflora, pyloric ligation

Abstract

The anti ulcerogenic activity of Sesbania graindiflora was evaluated by employing aspirin and pylorus ligation induced ulcerations in rats. Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin are known to induce gastric ulceration. The reason being attributed principally to inhibition of biosynthesis of ‘cytoprotective prostaglandins’ (by inhibition of cyclo-oxygenase pathway of arachidonic acid metabolism), resulting in overproduction of leukotrienes and other products of 5-lipoxygenase pathway. Hence, the protective action of Sesbania graindiflora against aspirin- induced gastric lesions could possibly be due to its 5-lipoxygenase inhibitory effect.

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Published

2010-12-01

Issue

Vol. 1 No. 4 (2010): Nov

Section

Original Research Articles

License

Copyright (c) 2010 International Journal of Biomedical Research

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How to Cite

1.
ANTIULCER ACTIVITY OF THE METHANOLIC EXTRACT OF SESBANIA GRAINDIFLORA. Int Jour of Biomed Res [Internet]. 2010 Dec. 1 [cited 2026 Mar. 9];1(4):163-70. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/625