PROTECTIVE EFFECT OF NERIUM INDICUM ON CCl4 INDUCED HEPATOTOXICITY IN RATS
DOI:
https://doi.org/10.7439/ijbr.v1i4.68Keywords:
Psychiatric Centers, Architecture, SchizophreniaAbstract
Methanolic flowers extract of Nerium indicum was evaluated for hepatoprotective in rats. The plant extract (500 and 1000 mg/kg, p.o.) showed a remarkable hepatoprotective activity against carbon tetrachloride induced hepatotoxicity in liver tissues. Carbon tetrachloride induced a significant rise in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT) and alkaline phosphatase (ALP). Treatment of rats with different doses of plant extract (500 and 1000 mg/kg) significantly (P 0.001) altered serum marker enzymes levels to against carbon tetrachloride treated rats. The activity of the extract at dose of 300 mg/kg was comparable to the standard drug, silymarin (100 mg/kg, p.o.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective properties of Nerium indicum against carbon tetrachloride induced hepatotoxicity in rats.
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