ANTIULCER ACTIVITY OF METHANOLIC LEAVES EXTRACT OF NERIUM INDICUM MILL.

Authors

  • Govind Patel Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh
  • Satish Nayak Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh
  • Shobhit Shrivastava Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal 462021, Madhya Pradesh

DOI:

https://doi.org/10.7439/ijbr.v1i2.59

Keywords:

Indomethacin, pylorus ligation

Abstract

The objective of present study is to evaluate the anti ulcer activity of methanol extract of leaves of Nerium indicum. The methanol extract of N. indicum was investigated for its anti ulcer activity against plus pylorus ligation induced gastric ulcer and indomethacin induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity, total acidity, pH and ulcer inhibition in plus pylorus ligation induced gastric ulcer model and mean score value of ulcer inhibition in indomethacin induced ulcer model. A significant antiulcer activity was observed in all the models. Pylorus ligation model showed significant (P 0.001, P 0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed 69.63 % ulcer inhibition in indomethacin induced ulcer. This present study indicates that Nerium indicum leaves extract have potential anti ulcer activity in the two models tested.

Downloads

Download data is not yet available.

Downloads

Published

2010-10-01

Issue

Vol. 1 No. 2 (2010): Sep

Section

Original Research Articles

License

Copyright (c) 2010 International Journal of Biomedical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • An author must submit Copyright form After acceptance of the article.

How to Cite

1.
ANTIULCER ACTIVITY OF METHANOLIC LEAVES EXTRACT OF NERIUM INDICUM MILL. Int Jour of Biomed Res [Internet]. 2010 Oct. 1 [cited 2026 Mar. 8];1(2):55-61. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/614